Área de Genómica
Noguerales, V., Arjona, Y., García-Olivares, V., Machado, A., López, H., Patiño, J., & Emerson, B. C. (2024). Genetic legacies of mega-landslides: Cycles of isolation and contact across flank collapses in an oceanic island. Molecular ecology 2024;33(9):e17341. doi: https://doi.org/10.1111/mec.17341
Guillén, R., Salinas, C., Mendoza-Álvarez, A., Rubio Rodríguez, L. A., Díaz-de Usera, A., Lorenzo-Salazar, J. M., González-Montelongo, R., Flores, C., & Rodríguez, F. (2024). Genomic epidemiology of the primary methicillin-resistant Staphylococcus aureus clones causing invasive infections in Paraguayan children. Microbiology spectrum, e0301223. doi: https://doi.org/10.1128/spectrum.03012-23
Almeida Silvia Diz-de, Cruz Raquel, Luchessi Andre D., Lorenzo-Salazar José M., de Heredia Miguel López, Quintela Inés, González-Montelongo Rafaela, Silbiger Vivian N., Porras Marta Sevilla, Castaño Jair Antonio Tenorio, Nevado Julian, Aguado Jose María, Aguilar Carlos, Aguilera-Albesa Sergio, Almadana Virginia, Almoguera Berta, Alvarez Nuria, Andreu-Bernabeu Álvaro, Arana-Arri Eunate, Arango Celso, Arranz María J., Artiga Maria-Jesus, Baptista-Rosas Raúl C., Sánchez María Barreda-, Belhassen-Garcia Moncef, Bezerra Joao F., Bezerra Marcos A.C., Boix-Palop Lucía, Brion María, Brugada Ramón, Bustos Matilde, Calderón Enrique J., Carbonell Cristina, Castano Luis, Castelao Jose E., Vicente Rosa Conde-, Cordero-Lorenzana M. Lourdes, Cortes-Sanchez Jose L., Corton Marta, Darnaude M. Teresa, Martino-Rodríguez Alba De, del Campo-Pérez Victor, de Bustamante Aranzazu Diaz, Domínguez-Garrido Elena, Eirós Rocío, Fariñas María Carmen, Fernandez-Nestosa María J., Fernández-Robelo Uxía, Fernández-Rodríguez Amanda, Fernández-Villa Tania, Gago-Domínguez Manuela, Gil-Fournier Belén, Arrue Javier Gómez-, Álvarez Beatriz González, de Quirós Fernan Gonzalez Bernaldo, González-Neira Anna, González-Peñas Javier, Gutiérrez-Bautista Juan F., Herrero María José, Herrero-Gonzalez Antonio, Jimenez-Sousa María A., Lattig María Claudia, Borja Anabel Liger, Lopez-Rodriguez Rosario, Mancebo Esther, López Caridad Martín-, Martín Vicente, Martinez-Nieto Oscar, Martinez-Lopez Iciar, Martinez-Resendez Michel F., Martinez-Perez Ángel, Mazzeu Juliana F., Macías Eleuterio Merayo, Minguez Pablo, Cuerda Victor Moreno, Oliveira Silviene F., Ortega-Paino Eva, Parellada Mara, Paz-Artal Estela, Santos Ney P.C., Matute Patricia Pérez-, Perez Patricia, Pérez-Tomás M. Elena, Perucho Teresa, Abuin Mel·lina Pinsach-, Pita Guillermo, Pompa-Mera Ericka N., Porras-Hurtado Gloria L., Pujol Aurora, León Soraya Ramiro, Resino Salvador, Fernandes Marianne R., Rodríguez-Ruiz Emilio, Rodriguez-Artalejo Fernando, Rodriguez-Garcia José A., Ruiz-Cabello Francisco, Ruiz-Hornillos Javier, Ryan Pablo, Soria José Manuel, Souto Juan Carlos, Tamayo Eduardo, Tamayo-Velasco Alvaro, Taracido-Fernandez Juan Carlos, Teper Alejandro, Torres-Tobar Lilian, Urioste Miguel, Valencia-Ramos Juan, Yáñez Zuleima, Zarate Ruth, de Rojas Itziar, Ruiz Agustín, Sánchez Pascual, Real Luis Miguel, SCOURGE Cohort Group , Guillen-Navarro Encarna, Ayuso Carmen, Parra Esteban, Riancho José A., Rojas-Martinez Augusto, Flores Carlos, Lapunzina Pablo, Carracedo Ángel (2024). Novel risk loci for COVID-19 hospitalization among admixed American populations. eLife 13:RP93666. doi: https://doi.org/10.7554/eLife.93666.1
García-Solís B., Tapia-Torres M., García-Soidán A., Hernández-Brito E., Martínez-Saavedra M.T., Lorenzo Salazar J.M., García-Hernández S., Van Den Rym A., Mayani Mayani K., Govantes-Rodríguez J.V., Gervais A., Bastard P., Puel A., Casanova J-L., Flores C., Pérez de Diego R., Rodríguez-Gallego C. (2024). Immunoglobulin G4-related disease and B-cell malignancy due to an IKZF1 gain-of-function variant. The Journal of allergy and clinical immunology, S0091-6749(24)00330-0. doi: https://doi.org/10.1016/j.jaci.2024.03.018
Pérez-Jurado, L. A., Cáceres, A., Balagué-Dobón, L., Esko, T., López de Heredia, M., Quintela, I., Cruz, R., Lapunzina, P., Carracedo, Á., SCOURGE Cohort Group*, & González, J. R. (2024). Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2. González-Montelongo R., Íñigo-Campos A., Lorenzo-Salazar J.M. y Flores C. son miembros del grupo*. Communications biology, 7(1), 202. doi: https://doi.org/10.1038/s42003-024-05805-6
Esteban ME, Pino D, Romero-Lorca A, Novillo A, Gaibar M, Riancho JA, Rojas-Martínez A, Flores C, Lapunzina P, Carracedo Á; SCOURGE Cohort Group; Athanasiadis G, Fernández-Santander A. Worldwide distribution of genetic factors related to severity of COVID-19 infection. Ann Hum Biol. 2024 Feb;51(1):2366248. doi: https://doi.org/10.1080/03014460.2024.2366248
Serradell J.M., Lorenzo-Salazar J.M., Flores C., Lao O., & Comas D. Modelling the demographic history of human North African genomes points to a recent soft split divergence between populations. Genome Biology 25, 201 (2024). doi: https://doi.org/10.1186/s13059-024-03341-4
Marchal A, Cirulli ET, Neveux I, Bellos E, Thwaites RS, Schiabor Barrett KM, Zhang Y, Nemes-Bokun I, Kalinova M, Catchpole A, Tangye SG, Spaan AN, Lack JB, Ghosn J, Burdet C, Gorochov G, Tubach F, Hausfater P; COVID Human Genetic Effort; COVIDeF Study Group; French COVID Cohort Study Group; CoV-Contact Cohort; COVID-STORM Clinicians; COVID Clinicians*; Orchestra Working Group; Amsterdam UMC COVID-19 Biobank; NIAID-USUHS COVID Study Group; Dalgard CL, Zhang SY, Zhang Q, Chiu C, Fellay J, Grzymski JJ, Sancho-Shimizu V, Abel L, Casanova JL, Cobat A, Bolze A. Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection. HGG Adv. 2024 18;5(3):100300. Muñoz-Barrera A, Íñigo-Campos A, González-Montelongo R, Lorenzo-Salazar JM y Flores C son miembros del grupo *. doi: https://doi.org/10.1016/j.xhgg.2024.100300.
Pairo-Castineira E, Rawlik K, Bretherick AD, Qi T, Wu Y, Nassiri I, McConkey GA, Zechner M, Klaric L, Griffiths F, Oosthuyzen W, Kousathanas A, Richmond A, Millar J, Russell CD, Malinauskas T, Thwaites R, Morrice K, Keating S, Maslove D, Nichol A, Semple MG, Knight J, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Begg C, Walsh T, Tenesa A, Flores C, Riancho JA, Rojas-Martinez A, Lapunzina P; GenOMICC Investigators; SCOURGE Consortium; ISARICC Investigators; 23andMe COVID-19 Team; Yang J, Ponting CP, Wilson JF, Vitart V, Abedalthagafi M, Luchessi AD, Parra EJ, Cruz R, Carracedo A, Fawkes A, Murphy L, Rowan K, Pereira AC, Law A, Fairfax B, Hendry SC, Baillie JK. GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. Nature. 2023 May;617(7962):764-768. doi: https://doi.org/10.1038/s41586-023-06034-3
Suarez-Pajes E, Marcelino-Rodriguez I, Hernández Brito E, Gonzalez-Barbuzano S, Ramirez-Falcon M, Tosco-Herrera E, Rubio-Rodríguez LA, Briones ML, Rajas O, Borderías L, Ferreres J, Payeras A, Lorente L, Aspa J, Lorenzo Salazar JM, Valencia-Gallardo JM, Carbonell N, Freixinet JL, Rodríguez de Castro F, Solé Violán J, Flores C, Rodríguez-Gallego C. (2024). A genome-wide association study of adults with community-acquired pneumonia. Respiratory Research 25(1), 374. doi: https://doi.org/10.1186/s12931-024-03009-4
Hu, X., Kim, J. S., Saferali, A., Huang, Y., Ma, S. F., Bingham, G. C., Bonham, C. A., Flores, C., Castaldi, P., Hersh, C. P., Cho, M. H., IPF Survival GWAS Consortium *, Noth, I., & Manichaikul, A. (2024). Transcriptome-Wide Association Study of Idiopathic Pulmonary Fibrosis Survival Identifies PTPN9 and SNRPB2. American journal of respiratory and critical care medicine, 210(5), 683–686. Lorenzo-Salazar JM es miembro del grupo *. doi: https://doi.org/10.1164/rccm.202310-1741LE
Guillen-Guio B., Marcelino-Rodriguez I., Lorenzo-Salazar J.M., Leavy O.C., Allen R. J., Pompa-Mera E.N., Riancho J.A., Rojas-Martínez A., Lapunzina P., Carracedo Á., Wain L.V., Flores C. Polygenic risk of idiopathic pulmonary fibrosis and COVID-19 severity. ERJ Open Research 2024; 00978-2024. doi: https://doi.org/10.1183/23120541.00978-2024
Guillen-Guio B, Paynton ML, Allen RJ, Chin DPW, Donoghue LJ, Stockwell A, Leavy OC, Hernandez-Beeftink T, Reynolds C, Cullinan P, Martinez F, Booth HL, Fahy WA, Hall IP, Hart SP, Hill MR, Hirani N, Hubbard RB, McAnulty RJ, Millar AB, Navaratnam V, Oballa E, Parfrey H, Saini G, Sayers I, Tobin MD, Whyte MKB, Adegunsoye A, Kaminski N, Ma SF, Strek ME, Zhang Y, Fingerlin TE, Molina-Molina M, Neighbors M, Sheng XR, Oldham JM, Maher TM, Molyneaux PL, Flores C, Noth I, Schwartz DA, Yaspan BL, Jenkins RG, Wain LV, Hollox EJ (2024). Association study of human leukocyte antigen variants and idiopathic pulmonary fibrosis. ERJ Open Res.2024 Feb 19;10(1):00553-2023. doi: https://doi.org/10.1183/23120541.00553-2023
Bastard P, Gervais A, Taniguchi M, Saare L, Särekannu K, Le Voyer T, Philippot Q, Rosain J, Bizien L, Asano T, Garcia-Prat M, Parra-Martínez A, Migaud M, Tsumura M, Conti F, Belot A, Rivière JG, Morio T, Tanaka J, Javouhey E, Haerynck F, Duvlis S, Ozcelik T, Keles S, Tandjaoui-Lambiotte Y, Escoda S, Husain M, Pan-Hammarström Q, Hammarström L, Ahlijah G, Abi Haidar A, Soudee C, Arseguel V, Abolhassani H, Sahanic S, Tancevski I, Nukui Y, Hayakawa S, Chrousos GP, Michos A, Tatsi EB, Filippatos F, Rodriguez-Palmero A, Troya J, Tipu I, Meyts I, Roussel L, Ostrowski SR, Schidlowski L, Prando C, Condino-Neto A, Cheikh N, Bousfiha AA, El Bakkouri J; COVID Clinicians; GEN-COVID Study Group; COVID Human Genetic Effort*; Peterson P, Pujol A, Lévy R, Quartier P, Vinh DC, Boisson B, Béziat V, Zhang SY, Borghesi A, Pession A, Andreakos E, Marr N, Mentis AA, Mogensen TH, Rodríguez-Gallego C, Soler-Palacin P, Colobran R, Tillmann V, Neven B, Trouillet-Assant S, Brodin P, Abel L, Jouanguy E, Zhang Q, Martinón-Torres F, Salas A, Gómez-Carballa A, Gonzalez-Granado LI, Kisand K, Okada S, Puel A, Cobat A, Casanova JL (2024). Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children. J Exp Med. 2024 Feb 5;221(2):e20231353. *Flores C es miembro del grupo. doi: https://doi.org/10.1084/jem.20231353
Andreakos E; COVID Human Genetic Effort* (2024). Type I and type III interferons: From basic biology and genetics to clinical development for COVID-19 and beyond. Semin Immunol. 2024 Mar;72:101863. *Flores C es miembro del grupo. doi: https://doi.org/10.1016/j.smim.2024.101863.
Gonzalez-Barbuzano S, León-Hernández A, Suárez-Pajes E, Marcelino-Rodriguez I, Flores C (2024). Mapeo por mezcla para identificar nuevos factores genéticos de riesgo de enfermedades y su aplicación en la población de las Islas Canarias. Revista Española de Endocrinología Pediátrica 2024, 15 (suppl 2): 40-46. doi: https://doi.org/10.3266/RevEspEndocrinolPediatr.pre2024.Apr.895
Wagner J, Olson ND, McDaniel J, Harris L, Pinto BJ, Jáspez D, Muñoz-Barrera A, Rubio-Rodríguez LA, Lorenzo-Salazar JM, Flores C, Sahraeian SME, Narzisi G, Byrska-Bishop M, Evani US, Xiao C, Lake JA, Fontana P, Greenberg C, Freed D, Mootor MFE, Boutros PC, Murray L, Shafin K, Carroll A, Sedlazeck FJ, Wilson M, Zook JM (2024). Small variant benchmark from a complete assembly of X and Y chromosomes. Nature Communications 2024, en prensa. doi: https://doi.org/10.1101/2023.10.31.564997
Ramírez-Olivencia G, Velasco Arribas M, Vera García MM, Casabona J, Martínez MJ, Membrillo De Novales FJ; CEME-22 Study Group* (2022). Clinical and Epidemiological Characteristics of the 2022 Mpox Outbreak in Spain (CEME-22 Study). Open Forum Infectious Diseases 2024, 11: ofae105. *Alcoba-Florez J es miembro del grupo. doi: https://doi.org/10.1093/ofid/ofae105
Nóvoa-Medina Y, Marcelino-Rodriguez I, Suárez NM, Barreiro-Bautista M, Rivas-García E, Sánchez-Alonso S, González-Martínez G, Quinteiro-González S, Domínguez Á, Cabrera M, López S, Pavlovic S, Flores C; Gran Canarian Diabetes and Obesity Research Group; Wägner AM (2024). Does HLA explain the high incidence of childhood-onset type 1 diabetes in the Canary Islands? The role of Asp57 DQB1 molecules. BMC Pediatr. 2024 Sep 6;24(1):569. doi: https://doi.org/10.1186/s12887-024-04983-w
Bellos E, Santillo D, Vantourout P, Jackson HR, Duret A, Hearn H, Seeleuthner Y, Talouarn E, Hodeib S, Patel H, Powell O, Yeoh S, Mustafa S, Habgood-Coote D, Nichols S, Estramiana Elorrieta L, D’Souza G, Wright VJ, Estrada-Rivadeneyra D, Tremoulet AH, Dummer KB, Netea SA, Condino-Neto A, Lau YL, Núñez Cuadros E, Toubiana J, Holanda Pena M, Rieux-Laucat F, Luyt CE, Haerynck F, Mège JL, Chakravorty S, Haddad E, Morin MP, Metin Akcan Ö, Keles S, Emiroglu M, Alkan G, Tüter Öz SK, Elmas Bozdemir S, Morelle G, Volokha A, Kendir-Demirkol Y, Sözeri B, Coskuner T, Yahsi A, Gulhan B, Kanik-Yuksek S, Bayhan GI, Ozkaya-Parlakay A, Yesilbas O, Hatipoglu N, Ozcelik T, Belot A, Chopin E, Barlogis V, Sevketoglu E, Menentoglu E, Gayretli Aydin ZG, Bloomfield M, AlKhater SA, Cyrus C, Stepanovskiy Y, Bondarenko A, Öz FN, Polat M, Fremuth J, Lebl J, Geraldo A, Jouanguy E; COVID-19 Human Genetic Effort*; DIAMONDS; EUCLIDS; Carter MJ, Wellman P, Peters M, Pérez de Diego R, Edwards LA, Chiu C, Noursadeghi M, Bolze A, Shimizu C, Kaforou M, Hamilton MS, Herberg JA, Schmitt EG, Rodriguez-Palmero A, Pujol A, Kim J, Cobat A, Abel L, Zhang SY, Casanova JL, Kuijpers TW, Burns JC, Levin M, Hayday AC, Sancho-Shimizu V (2024). Heterozygous BTNL8 variants in individuals with multisystem inflammatory syndrome in children (MIS-C). J Exp Med. 2024 Dec 2;221(12):e20240699. *Flores C es miembro del grupo. doi: https://doi.org/10.1084/jem.20240699
Duminy-Luppi D, Alcaide-Aldeano A, Planas-Cerezales L, Bermudo G, Vicens-Zygmunt V, Luburich P, Del Río-Carrero B, Llatjós R, Pijuan L, Escobar I, Rivas F, Montes-Worboys A, Gutiérrez-Rodríguez Y, Rodríguez-Plaza D, Padró-Miquel A, Esteve-Garcia A, Fernández-Varas B, Flores C, Fuentes M, Dorca J, Santos S, Perona R, Günther A, Shull J, Molina-Molina M (2024). Diagnostic and prognostic implications of family history of fibrotic interstitial lung diseases. Respir Res. 2024 Dec 18;25(1):433. doi: https://doi.org/10.1186/s12931-024-03063-y
Ramirez-Falcon M, Suarez-Pajes E, Flores C (2024). Defining the Differential Corticosteroid Response Basis from Multiple Omics Approaches. Int J Mol Sci. 2024 Dec 19;25(24):13611. doi: https://doi.org/10.3390/ijms252413611.
Al Qureshah F, Le Pen J, de Weerd NA, Moncada-Velez M, Materna M, Lin DC, Milisavljevic B, Vianna F, Bizien L, Lorenzo L, Lecuit M, Pommier JD, Keles S, Ozcelik T, Pedraza-Sanchez S, de Prost N, El Zein L, Hammoud H, Ng LFP, Halwani R, Saheb Sharif-Askari N, Lau YL, Tam AR, Singh N, Bhattad S, Berkun Y, Chantratita W, Aguilar-López R, Shahrooei M; COVID-19 HGE Consortium*; SEAe Consortium; Abel L, Bastard P, Jouanguy E, Béziat V, Zhang P, Rice CM, Cobat A, Zhang SY, Hertzog PJ, Casanova JL, Zhang Q (2024). A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity. J Exp Med. 2025 Feb 3;222(2):e20241413; Epub 2024 Dec 16. *Flores C es miembro del grupo. doi: https://doi.org/10.1084/jem.20241413.