Área de Genómica
The COVID-19 Host Genetics Initiative (Carlos Flores, Jose M. Lorenzo-Salazar y Rafaela Gonzalez Montelongo). A second update on mapping the human genetic architecture of COVID-19. Nature 621, E7–E26 (2023). doi: https://doi.org/10.1038/s41586-023-06355-3
Pairo-Castineira, Erola; Rawlik, Konrad; Bretherick, Andrew D.; Qi, Ting; Wu, Yang; Nassiri, Isar; McConkey, Glenn A.; Zechner, Marie; Klaric, Lucija; Griffiths, Fiona; Oosthuyzen, Wilna; Kousathanas, Athanasios; Richmond, Anne; Millar, Jonathan; Russell, Clark D.; Malinauskas, Tomas; Thwaites, Ryan; Morrice, Kirstie; Keating, Sean; Maslove, David; Nichol, Alistair; Semple, Malcolm G.; Knight, Julian; Shankar-Hari, Manu; Summers, Charlotte; Hinds, Charles; Horby, Peter; Ling, Lowell; McAuley, Danny; Montgomery, Hugh; Openshaw, Peter J. M.; Begg, Colin; Walsh, Timothy; Tenesa, Albert; Flores, Carlos; Riancho, José A.; Rojas-Martinez, Augusto; Lapunzina, Pablo; Clohisey, Sara; Millar, Johnny; Shankar-Hari, Manu; Aitkin, Emma; Aravindan, Latha; Armstrong, Ruth; Baillie, J. Kenneth. GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19. Nature (2023). doi: https://doi.org/10.1038/s41586-023-06034-3
Tangye SG; COVID Human Genetic Effort consortium*. Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity. J Allergy Clin Immunol. 2023 Apr;151(4):818-831. Flores C es miembro del grupo*. doi: https://doi.org/10.1016/j.jaci.2022.11.010.
Carl J Reynolds, Fabiola Del Greco M, Richard J Allen, Carlos Flores, R Gisli Jenkins, Toby M Maher, Philip L Molyneaux, Imre Noth, Justin M Oldham, Louise V Wain, Jiyuan An, Jue-Sheng Ong, Stuart MacGregor, Tom A. Yates, Paul Cullinan, Cosetta Minelli. The causal relationship between gastro-esophageal reflux disease and idiopathic pulmonary fibrosis: A bidirectional two-sample Mendelian randomization study. Eur Respir J. 2023 May 25;61(5):2201585. doi: https://doi.org/10.1183/13993003.01585-2022
Ana García-García, Rebeca Pérez de Diego, Carlos Flores, Darawan Rinchai, Jordi Solé-Violán, Àngela Deyà-Martínez, Blanca García-Solis, José M. Lorenzo-Salazar, Elisa Hernández-Brito, Anna-Lisa Lanz, Leen Moens, Giorgia Bucciol, Mohamed Almuqamam, Joseph B. Domachowske, Elena Colino, Juan Luis Santos-Perez, Francisco M. Marco, Claudio Pignata, Aziz Bousfiha, Stuart E. Turvey, Stefanie Bauer, Filomeen Haerynck, Javier Gonzalo Ocejo-Vinyals, Francisco Lendinez, Seraina Prader, Nora Naumann-Bartsch, Jana Pachlopnik Schmid, Catherine M. Biggs, Kyla Hildebrand, Alexandra Dreesman, Miguel Ángel Cárdenes, Fatima Ailal, Ibtihal Benhsaien, Giuliana Giardino, Agueda Molina-Fuentes, Claudia Fortuny, Swetha Madhavarapu, Daniel H. Conway, Carolina Prando, Laire Schidlowski, María Teresa Martínez de Saavedra Álvarez, Rafael Alfaro, Felipe Rodríguez de Castro, ESID Registry Working Party, COVID Human Genetic Effort, Isabelle Meyts, Fabian Hauck, Anne Puel, Paul Bastard, Bertrand Boisson, Emmanuelle Jouanguy, Laurent Abel, Aurélie Cobat, Qian Zhang, Jean-Laurent Casanova, Laia Alsina, Carlos Rodríguez-Gallego. Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia. Journal of Experimental Medicine 1 May 2023; 220 (5): e20220170. doi: https://doi.org/10.1084/jem.20220170
Lee D, Le Pen J, Yatim A, […] C. Flores, [..] et al. Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children. Science 2023;379(6632):eabo3627. doi: https://doi.org/10.1126/science.abo3627
Bucciol G, COVID Human Genetic Effort*, Meyts I. Inherited and acquired errors of type I interferon immunity govern susceptibility to COVID-19 and multisystem inflammatory syndrome in children. J Allergy Clin Immunol. 2023;S0091-6749(23)00176-8. Flores C es miembro del grupo*. doi: https://doi.org/10.1016/j.jaci.2023.02.003
Adrián Muñoz-Barrera, Laura Ciuffreda, Julia Alcoba-Florez, Luis A. Rubio-Rodríguez, Héctor Rodríguez-Pérez, Helena Gil-Campesino, Diego García-Martínez de Artola, Josmar Salas-Hernández, Julia Rodríguez-Núñez, Antonio Íñigo-Campos, Víctor García-Olivares, Oscar Díez-Gil, Rafaela González-Montelongo, Agustín Valenzuela-Fernández, José M. Lorenzo-Salazar, Carlos Flores. Bioinformatic approaches to draft the viral genome sequence of Canary Islands cases related to the multi-country Monkeypox virus 2022-outbreak. Computational and Structural Biotechnology Journal, March 15, 2023. doi: https://doi.org/10.1016/j.csbj.2023.03.020
Justin M. Oldham, Richard J Allen, Jose M. Lorenzo-Salazar, Philip L Molyneaux, Shwu-Fan Ma, Chitra Joseph, John S. Kim, Beatriz Guillen-Guio, Tamara Hernández-Beeftink, Jonathan A Kropski, Yong Huang, Cathryn T. Lee, Ayodeji Adegunsoye, Janelle Vu Pugashetti, Angela L Linderholm, Vivian Vo, Mary E. Strek, Jonathan Jou, Adrian Muñoz-Barrera, Luis A. Rubio-Rodriguez, Richard Hubbard; Nik Hirani, Moira K. B. Whyte, Simon Hart, Andrew G Nicholson; Lisa Lancaster, Helen Parfrey, Doris Rassl, William Wallace, Eleanor Valenzi, Yingze Zhang, Josyf Mychaleckyj, Amy Stockwell, Naftali Kaminski, Paul J Wolters, Maria Molina-Molina, Nicholas E Banovich, William A Fahy, Fernando J. Martinez, Ian P. Hall, Martin D Tobin, Toby M. Maher, Timothy S Blackwell, Brian L Yaspan, R Gisli Jenkins, Carlos Flores, Louise V Wain, Imre Noth. PCSK6 and Survival in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2023;10.1164/rccm.202205-0845OC. doi: https://doi.org/10.1164/rccm.202205-0845OC
Matuozzo, D., Talouarn, E., Marchal, A., COVID Human Genetic Effort* et al. Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19. Genome Med 15, 22 (2023). Flores C es miembro del grupo*. doi:https://doi.org/10.1186/s13073-023-01173-8
Justin M. Oldham, Richard J Allen, Jose M. Lorenzo-Salazar, Carlos Flores, Louise V Wain, and Imre Noth. Reply to: PCSK6: The endogenous PAR-1 agonist driving pulmonary fibrosis? Am J Respir Crit Care Med. 2023;10.1164/rccm.202303-0402LE. doi: https://doi.org/10.1164/rccm.202303-0402LE
Su HC, Jing H, Zhang Y, COVID Human Genetic Effort*, Casanova JL. Interfering with interferons: A critical mechanism for critical COVID-19 pneumonia. Annual Review of Immunology, 2023, 41: 561-585. *Carlos Flores es miembro del grupo. doi: https://doi.org/10.1146/annurev-immunol-101921-050835
URL: https://www.annualreviews.org/doi/abs/10.1146/annurev-immunol-101921-050835
Vázquez-Morón S, Iglesias-Caballero M, Lepe JA, Garcia F, Melón S, Marimon JM, García de Viedma D, Folgueira MD, Galán JC, López-Causapé C, Benito-Ruesca R, Alcoba-Florez J, Gonzalez Candelas F, Toro Md, Fajardo M, Ezpeleta C, Lázaro F, Pérez Castro S, Cuesta I, Zaballos A, Pozo F, Casas I, on behalf of RELECOV Network Members*. Enhancing SARS-CoV-2 Surveillance through Regular Genomic Sequencing in Spain: The RELECOV Network. International Journal of Molecular Sciences. 2023; 24(10):8573. Rafaela González Montelongo y Jose M. Lorenzo-Salazar son miembros del grupo*. doi: https://doi.org/10.3390/ijms24108573
Alonso-Gonzalez A, Tosco-Herrera E, Molina-Molina M, Flores C. Idiopathic pulmonary fibrosis and the role of genetics in the era of precision medicine. Front Med (Lausanne). 2023;10:1152211. doi: https://doi.org/10.3389/fmed.2023.1152211
Alemany-Navarro, M., Diz-de Almeida, S., Cruz, R., Riancho, J. A., Rojas-Martínez, A., Lapunzina, P., Flores, C., Scourge Cohort Group, & Carracedo, A.
Psychiatric polygenic risk as a predictor of COVID-19 risk and severity: insight into the genetic overlap between schizophrenia and COVID-19. Transl Psychiatry. 2023;13(1):189. URL:https://www.nature.com/articles/s41398-023-02482-7. doi: https://doi.org/10.1038/s41398-023-02482-7
Eva Suarez-Pajes, Eva Tosco-Herrera, Melody Ramirez-Falcon, Silvia Gonzalez-Barbuzano, Tamara Hernandez-Beeftink, Beatriz Guillen-Guio, Jesús Villar, Carlos Flores. Genetic determinants of the acute respiratory distress syndrome. Journal of Clinical Medicine 12(11):3713 URL: https://www.mdpi.com/2077-0383/12/11/3713. doi: https://doi.org/10.3390/jcm12113713
Ciuffreda, Laura, Lorenzo-Salazar, José M., García-Martínez de Artola, Diego, Gil-Campesino, Helena, Alcoba-Florez, Julia, Rodríguez-Pérez, Héctor, Íñigo-Campos, Antonio, Salas-Hernández, Josmar, Rodríguez-Nuñez, Julia, Muñoz-Barrera, Adrián, Valenzuela-Fernández, Agustín, Díez-Gil, Oscar, González-Montelongo, Rafaela, Flores, Carlos. Reinfection rate and disease severity of the BA.5 Omicron SARS-CoV-2 lineage compared to previously circulating variants of concern in the Canary Islands (Spain). Emerg Microbes Infect. 12,1. doi: https://doi.org/10.1080/22221751.2023.2202281
Allen RJ, Oldham JM, Jenkins DA, Leavy OC, Guillen-Guio B, Melbourne CA, Ma SF, Jou J, Kim JS; CleanUP-IPF Investigators of the Pulmonary Trials Cooperative; Fahy WA, Oballa E, Hubbard RB, Navaratnam V, Braybrooke R, Saini G, Roach KM, Tobin MD, Hirani N, Whyte MKB, Kaminski N, Zhang Y, Martinez FJ, Linderholm AL, Adegunsoye A, Strek ME, Maher TM, Molyneaux PL, Flores C, Noth I, Gisli Jenkins R, Wain LV. Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study. Lancet Respir Med. 2023 Jan;11(1):65-73. doi: https://doi.org/10.1016/S2213-2600(22)00251-X
Castro-Santos P, Rojas-Martinez A, Riancho JA, Lapunzina P, Flores C, Carracedo Á, Díaz-Peña R; Scourge Cohort Group. HLA-A*11:01 and HLA-C*04:01 are associated with severe COVID-19. HLA. 2023 Dec;102(6):731-739. doi: https://doi.org/10.1111/tan.15160
García-Olivares V, Muñoz-Barrera A, Rubio-Rodríguez LA, Jáspez D, Díaz-de Usera A, Iñigo-Campos A, Veeramah KR, Alonso S, Thomas MG, Lorenzo-Salazar JM, González-Montelongo R, Flores C (2023). Benchmarking of human Y-chromosomal haplogroup classifiers with whole-genome and whole-exome sequence data. Comput Struct Biotechnol J. 2023 Sep 15;21:4613-4618. doi: https://doi.org/10.1016/j.csbj.2023.09.012
Área de Medioambiente
Cabrera-Pérez I., D’Auria L., Soubestre J., Przeor M., Barrancos J., García-Hernández R., Ibáñez J.M., Koulakov I., Martínez van Dorth D., Ortega V., Padilla G., Sagiya T. and Pérez N. M. (2023). Spatio-temporal velocity variations observed during the pre-eruptive episode of La Palma 2021 eruption inferred from ambient noise interferometry. Scientific Reports, 13(1), 12039. https://doi.org/10.1038/s41598-023-39237-9.
Birnbaum J., Lev E., Hernández P. A., Barrancos J., Padilla G. D., Asensio-Ramos M., Calvo D., Rodríguez F., Pérez N. M., D’Auria L. and Calvari S. (2023). Temporal variability of explosive activity at Tajoigate Volcano, Cumbre Vieja, 2021 eruption from ground-based infrared photography and videography. Frontiers in Earth Science, https://doi: 10.3389/feart.2023.1193436.
Wertheim D., Coldwell B., Miyashita L., Gill I., Crust S., Giddens R., Pérez M. M., Petford N. and Grigg J. (2023). Confocal microscopy 3D imaging and bioreactivity of La Palma volcanic ash particles. Science of The Total Environment, vol. 899, 165647, https://doi.org/10.1016/j.scitotenv.2023.165647.
Butcher A. R., Windmill R., Corfe I. J., Lim S., Ester M. Jolis E. M., Lukkari S., Pankhurst M. J., Barbee O. A., Coldwell B. C., Perez N. M., White L. F., Dunford A. and Anand M. (2023). Volcanic ash as a resource for future research on Earth and the Moon. Geology Today, Volume 39, Issue 4, Pages 144-148, https://doi.org/10.1111/gto.12442
Cabrera-Pérez I., Soubestre J., D’Auria L., Barrancos J., Martín-Lorenzo A., Martínez van Dorth D., Padilla G. D., Przeor M. and Pérez N.M. (2023). Geothermal and structural features of La Palma island (Canary Islands) imaged by ambient noise tomography. Scientific Reports 13, 12892, https://doi.org/10.1038/s41598-023-39910-z
Taddeucci J., Scarlato P., Andronico D., Ricci T., Civico R., Del Bello E.. Spina L., D’Auria L., Asensio-Ramos M., Calvo D., Padrón E., Hernández P. A. and Pérez N. M. (2023). The explosive activity of the 2021 Tajogaite eruption (La Palma, Canary Islands, Spain). Geochemistry, Geophysics, Geosystems, 24, e2023GC010946. https://doi.org/10.1029/2023GC010946
Bonadonna C., Pistolesi M., Dominguez L., Freret-Lorgeril V., Rossi E., Fries A., Biass S., Voloschina M., Lemus J., Romero J. E., Zanon V., Pastore C., Reyes Hardy Mary-Paz, Di Maio L. S., Gabellini P., Martin-Lorenzo A., Rodríguez F. and Perez N. M. (2023). Tephra sedimentation and grainsize associated with pulsatory activity: the 2021 Tajogaite eruption of Cumbre Vieja (La Palma, Canary Islands, Spain). Frontiers in Earth Science, https://doi.org/10.3389/feart.2023.1166073.
Asensio-Ramos M. and D’Orazio G. (2023). Capillary electromigration techniques: application to coffee analysis – A review. Journal of Chromatography Open, 3, 100083, https://doi.org/10.1016/j.jcoa.2023.100083.
Koulakov I., D’Auria L., Prudenci J., Cabrera-Pérez I., Barrancos J., Padilla G. D., Pérez M. M., and Ibáñez J. M. (2023).. Local earthquake seismic tomography reveals the link between crustal structure and volcanism in Tenerife (Canary Islands). Journal of Geophysical Research – Solid Earth, https://doi.org/10.1029/2022JB025798
Di Fiore F., Vona A., Scarani A., Giordano G., Romano C., Giordano D., Caricchi L., A. Martin-Lorenzo A., Rodríguez F., Coldwell B., Hernández P. A. and Pankhurst M. (2023). Experimental Constraints on the Rheology of Lavas From 2021 Cumbre Vieja Eruption (La Palma, Spain). Geophysical Research Letters, https://doi.org/10.1029/2022GL100970.
Aznar M., Sanz-Arranz A., Shkolyar S., Sawyers E. R., Konstantinidis M., Lopez-Reyes G., Veneranda M., Lymer E. A., Freemantle J. R., Daly M. G., Cloutis E. A., Rull-Perez F., Martinez-Frias J. and Lalla E. A. (2023). Raman-IR Spectroscopic, and XRD analysis of selected samples from Fogo Island, Cabo Verde: Implications for ancient Martian volcanology. Advances in Space Research, https://doi.org/10.1016/j.asr.2023.01.013.
Cabrera-Pérez I., Soubestre J., D’Auria L., Martínez van Dorth D., Ledo J., Piña-Varas P., Cervigón-Tomico G., Padilla G. D., Barrancos J. and Pérez N. M. (2023). Ambient noise tomography of Gran Canaria island (Canary Islands) for geothermal exploration. Geothermics, https://doi.org/10.1016/j.geothermics.2022.102609.
Chaminé H. I., Pires A., Fernandes I., Přikryl R., Tuğrul A., Şebnem Düzgün H. and González de Vallejo L. I. (2023). Engineering geosciences, geotechnics and functional geomaterials: new trends on GIS mapping, geotechnologies and design with geohazards. SN Applied Sciences, 5, 43, https://doi.org/10.1007/s42452-022-05213-7.
Piña-Varas P., Ledo J., Queralt P., Martínez van Dorth D., Marcuello A., Cabrera-Pérez I., D’Auria L. and Martí A.(2023). Volcanic monitoring of the 2021 La Palma eruption using long-period magnetotelluric data. Scientific Reports, 13, 15929. https://doi.org/10.1038/s41598-023-43326-0
Sandoval-Velasquez A., Rizzo A. L., Casetta F., Ntaflos T., Aiuppa A., Alonso M., Padrón E., Pankhurst M., Mundl-Petermeier A., Zanon V. and Pérez N.M. (2023). The noble gas signature of the 2021 Tajogaite eruption (La Palma, Canary Islands). Journal of Volcanology and Geothermal Research, https://doi.org/10.1016/j.jvolgeores.2023.107928.
Cabrera-Pérez I., Soubestre J., D’Auria L., Przeor M., García R., Barrancos J., Padilla G. D., Pérez N. M. and Prudencio (2023). Ambient noise tomography of El Hierro island (Canary Islands). Frontiers in Earth Science, Sec. Volcanology Volume 11 – 2023 | https://doi: 10.3389/feart.2023.1326634.
Dóniz-Páez, J., Becerra-Ramírez, R., Németh, K., Gosálvez, R. U., & Escobar, E. (2023). Geomorfositios de interés geoturístico del volcán monogenético Tajogaite, erupción de 2021 (La Palma, Islas Canarias, España). Geofísica Internacional, 63(1), 729–746. https://doi.org/10.22201/igeof.2954436xe.2024.63.1.1731
Reyes-Hardy M.-P., Biass S., Dominguez L., Di Maio L. S., Frischknecht C., Bonadonna C. and Pérez N. M. (2023). Temporal evolution of roof collapse from tephra fallout during the 2021-Tajogaite eruption (La Palma, Spain). Frontiers in Earth Science, Volume 11, https://doi: 10.3389/feart.2023.1303330
Hernández Gutiérrez L. E. y Povedano Marrugat E. (2023). Asignatura pendiente de la co‑gestión en el geoturismo: Análisis del Geoparque Global de El Hierro. PASOS, Journal of Tourism and Cultural Heritage, Vol. 21, Págs. 37-51, https://doi.org/10.25145/j.pasos.2023.21.003