2021

Área de Genómica

Alcoba-Florez J, Gil-Campesino H, García-Martínez de Artola D, Díez-Gil O, Valenzuela-Fernández A, González-Montelongo R, Ciuffreda L, Flores C. Increasing SARS-CoV-2 RT-qPCR testing capacity by sample pooling. International Journal of Infectious Diseases 2021;103:19-22. doi: https://doi.org/10.1016%2Fj.ijid.2020.11.155

Rodriguez-Perez H, Ciuffreda L, Flores C. NanoCLUST: a species-level analysis of 16S rRNA nanopore sequencing data. Bioinformatics 2021;37(11):1600-1601. doi: https://doi.org/10.1093/bioinformatics/btaa900

Lorenzo-Salazar JM, Muñoz-Barrera A, González-Montelongo R, Flores C. Whole-Genome Sequencing: From Samples to Variants and Beyond.
Capítulo de libro en “Bioinformatics and Human Genomics Research”, pp: 100-‌147. Ed. Diego Forero, CRC Press, USA (Taylor & Francis Group). doi: https://doi.org/10.1201/9781003005926

Leavy OC, Ma SF, Molyneaux PL, Maher TM, Oldham JM, Flores C, Noth I, Jenkins RG, Dudbridge F, Wain LV, Allen RJ. Proportion of idiopathic pulmonary fibrosis risk explained by known genetic loci. American Journal of Respiratory and Critical Care Medicine 2021;203(6):775-778.
doi: https://doi.org/10.1164/rccm.202008-3211le

Hernandez-Pacheco N, Gorenjak M, Jurgec S, Corrales A, Jorgensen A, Karimi L, Vijverberg SJ, Berce V, Schieck M, Acosta-Herrera M, Kerick M, Samedy-Bates L, Tavendale R, Villar J, Mukhopadhyay S, Pirmohamed M, Verhamme KMC, Kabesch M, Hawcutt DB, Turner S, Palmer CN, Burchard EG, Maitland-van der Zee AH, Flores C, Potočnik U, Pino-Yanes M. Combined analysis of transcriptomic and genetic data for the identification of loci involved in glucocorticosteroid response in asthma. Allergy 2021;76(4):1238-1243. doi: https://doi.org/10.1111/all.14552

Hernandez-Pacheco N, Vijverberg S, Herrera-Luis E, Li J, Sio Yang Y, Granell R, Corrales A, Maroteau C, Lethem R, Perez-Garcia J, Farzan N, Repnik K, Gorenjak M, Soares P, Karimi L, Schieck M, Pérez-Méndez L, Berce V, Tavendale R, Eng C, Sardón O, Kull I, Mukhopadhyay S, Pirmohamed M, Verhamme K, Burchard E, Kabesch M, Hawcutt D, Melén E, Potocnik U, Chew FT, Tantisira K, Turner S, Palmer C, Flores C, Pino-Yanes M, Maitland-van der Zee A-H.
Genome-wide association study of asthma exacerbations despite inhaled corticosteroids use. European Respiratory Journal 2021;57(5):2003388. doi: https://doi.org/10.1183/13993003.03388-2020

Planas-Cerezales L, Arias-Salgado EG, Berastegui C, Montes-Worboys A, González-Montelongo R, Lorenzo-Salazar JM, Vicens-Zygmunt V, Garcia Moyano M, Dorca J, Flores C, Perona R, Román A, Molina-Molina M. Lung transplant improves survival and quality of life regardless of telomere dysfunction. Frontiers in Medicine 2021;8:695919. doi: https://doi.org/10.3389/fmed.2021.695919

Novelli G, Liu J, Biancolella M, Alonzi T, Novelli A, Patten JJ, Cocciadiferro D, Agolini E, Colona VL, Rizzacasa B, Giannini R, Bigio B, Goletti D, Capobianchi MR, Grelli S, Mann J, McKee T, Cheng K, Amanat F, Krammer F, Guarracino A, Pepe G, Tomino C, Tandjaoui-Lambiotte Y, Uzunhan Y, Tubiana S, Ghosn J, COVID Human Genetic 19 Effort*, French COVID Cohort Study Group, CoV-Contact Cohort, Notarangelo LD, Su HC, Abel L, Cobat A, Elhanan G, Grzymski JJ, Latini A, Sidhu S, Jain S, Davey RA, Casanova JL, Wei W, Pandolfi PP. Inhibition of HECT E3 ligases as potential therapy for COVID-19.
Cell Death Dis. 2021;12(4):310. Flores C es miembro del grupo*. doi: https://doi.org/10.1038/s41419-021-03513-1

García-Olivares V, Muñoz-Barrera A, Lorenzo-Salazar JM, Zaragoza-Trello C, Rubio-Rodríguez LA, Díaz-de Usera A, Jáspez-Toledo D, Íñigo-Campos A, González-Montelongo R, Flores C. A benchmarking of human mitochondrial DNA haplogroup classifiers from whole-genome and whole-exome sequence data. Scientific Reports 2021;11(1):20510. doi: https://doi.org/10.1038/s41598-021-99895-5

Sancho-Shimizu V, Brodin P, Cobat A, Biggs CM, Toubiana J, Lucas CL, Henrickson SE, Belot A, MIS-C@CHGE*, Tangye SG, Milner JD, Levin M, Abel L, Bogunovic D, Casanova JL, Zhang SY. SARS-CoV-2-related MIS-C: a key to the viral and genetic causes of Kawasaki disease? Journal of Experimental Medicine 2021;218(6):e20210446. Flores C es miembro del grupo*. doi: https://doi.org/10.1084/jem.20210446

Ciuffreda L, Rodriguez-Perez H, Flores C. Nanopore sequencing and its application to the study of microbial communities. Computational and Structural Biotechnology Journal 2021;19:1497-1511. doi: https://doi.org/10.1016/j.csbj.2021.02.020

Alcoba-Florez J, Lorenzo-Salazar JM, Gil-Campesino H, Íñigo-Campos A, García-Martínez de Artola D, García-Olivares V, Díez-Gil O, Valenzuela-Fernández A, Ciuffeda L, González-Montelongo R, Flores C. Monitoring the rise of the SARS-CoV-2 lineage B.1.1.7 in Tenerife (Spain) since mid-December 2020. Journal of Infection 2021;82(6):e1-e3. doi: https://doi.org/10.1016/j.jinf.2021.04.005

Olaechea-Lázaro S, García O, González-Montelongo R, Lorenzo-Salazar JM, Flores C, López S, Veeramah KR, Hellenthal G, Thomas MG, Alonso S.
Complete mitogenome in a population sample from Cameroon. Forensic Science International Genetics 2021;55:102597. doi: https://doi.org/10.1016/j.fsigen.2021.102597

Arkin LM, Moon JM, Tran JM, Asgari S, O’Farrelly C, Casanova JL, Cowen EW, Mays JW, Singh AM, Drolet BA, COVID Human Genetic Effort*.
From your nose to your toes: A Review of SARS-CoV-2 Pandemic-associated Pernio. Journal of Investigative Dermatology 2021;141(12):2791-2796. Flores C es miembro del grupo*. doi: https://doi.org/10.1016/j.jid.2021.05.024

Asano T, Boisson B, Onodi F, Matuozzo D, Moncada M, Maglorius M, Meertens L, Bolze A, Materna M, Korniotis S, Gervais A, Bigio B, Seeleuthner Y, Bilguvar K, Zhang Y, Ogishi M, Pelham SJ, Soler-Palacín P, Colobran R, Martin-Nalda A, Rivière JG, Tandjaoui-Lambiotte Y, Chaibi K, Shahrooei M, Darazam IA, Olyaei NA, Mansouri D, Hatipoğlu N, Palabiyik F, Ozcelik T, Novelli G, Novelli A, Casari G, Aiuti A, Carrera P, Bondesan S, Barzaghi F, Querini PR, Tresoldi C, Franco JL, Reyes LF, Bustos IG, Arias A, Morelle G, Christèle K, Troya J, Planas-Serra L, Schlüter A, Gut M, Aurora-Pujol A, Allende LM, Flores C, Cabrera O, Pérez de Diego R, Rodriguez-Gallego C, Pleguezuelo GDE, Keles S, Dalgard C, Bonfanti P, Tubiana S, Burdet C, COVID Human Genetic Effort*, COVID-STORM Clinicians, COVID Clinicians**, Imagine COVID Group, French COVID Cohort Study Group, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank, NIAID-USUHS/TAGC COVID Immunity Group, Bustamante J, Puel A, Boisson-Dupuis S, Zhang SY, Béziat V, Lifton R, Bastard P, Notarangelo LD, Abel L, Su HC, Jouanguy E, Amara A, Soumelis V, Cobat A, Zhang Q, Casanova JL. X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19. Science Immunology 2021;6(62):eabl4348. Flores C es miembro de los grupos*,**. doi: https://doi.org/10.1126/sciimmunol.abl4348

Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Manry J, Michailidis E, Hoffmann HH, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Haljasmägi L, Migaud M, Särekannu K, Maslovskaja J, de Prost N, Tandjaoui-Lambiotte Y, Luyt CE, Amador-Borrero B, Gaudet A, Poissy J, Morel P, Richard P, Cognasse F, Troya J, Rivière J, Lorenzo L, Lagier JC, Gentile S, Trouillet-Assant S, Belot A, Saker K, Garçon P, Shaw E, Rosen LB, Moncada M, Arias A, Dalmau D, Tharaux PL, Sene D, Stepanian A, Megarbane B, Triantafyllia V, Heath JR, Franco JC, Ayana JM, Condino-Neto A, Imberti L, Biondi A, Castagnoli R, Bonfanti P, Delmonte OM, Zhang Y, Snow AL, Holland SM, Planas A, Haerynck F, Duvlis S, Nussbaum RL, Maniatis T, Ramirez C, Paul S, Hammarström PQ, Hammarström L, Dupont A, Kurolap A, Metz C, Aiuti A, Casari G, Lampasona V, Ciceri F, Barreiros LA, Vidaur L, van de Beek D, Tangye SG, Burrel S, Duffy D, Quintana-Murci L, Nussenzweig MC, Arrestier R, Anglicheau D, Boudhabhay I, Baris-Feldman H, Hagin D, Sharif-Askari NS, Halwani R, Dorgham K, Salette J, Sedkaoui SM, Vidigal M, Zatz M, Andreakos E, Sahanic S, Tancevski I, Fellay J, Lyonnet S, Bilguvar K, Lifton RP, HGID Lab, COVID CLINICIANS*, COVID-STORM Clinicians, NIAID Immune Response to COVID Group, French COVID Cohort Study Group, Imagine COVID-Group, The Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank Investigators, COVID Human Genetic Effort**, CONSTANCES cohort, Cohort 3 Cités, Cerba Health-Care, French Blood bank, Boisson B, Béziat V, Zhang SY, Vandreakos V, Hermine O, Pujol Onfre A, Peterson P, Mogensen TH, Rowen L, Mond J, Debette S, de Lamballerie X, Duval X, Mentré F, Zins M, Soler-Palacin P, Colobran R, Gorochov G, Moreno XS, Susen S, Martinez-Picado J, Raoult D, Vasse M, Gregersen PK, Piemonti L, Rodríguez-Gallego C, Notarangelo LD, Su HC, Kisand K, Okada S, Puel A, Jouanguy E, Rice CM, Tiberghien P, Zhang Q, Cobat A, Abel L, Casanova JL. Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths. Science Immunology 6: eabl4340. Flores C es miembro de los grupos*,**. Editorial dedicada: Kwon D. Rogue antibodies involved in almost one-fifth of COVID deaths. Nature 597, 162. Destacado en: Reynolds S. Misdirected antibodies linked to severe COVID-19. NIH Research News, 14 de septiembre de 2021. doi: https://www.nature.com/articles/d41586-021-02337-5

Casares-Marfil D, Guillen-Guio B, Lorenzo-Salazar JM, Rodríguez-Pérez H, Jaimes-Campos MA, Díaz ML, Estupiñán E, Echeverría LE, González CI, Martin J, Flores C*, Acosta-Herrera H. Admixture mapping analysis reveals differential genetic ancestry associated with Chagas disease susceptibility in the Colombian population. Human Molecular Genetics 2021;30(24):2503-2512. doi: https://doi.org/10.1093/hmg/ddab213

Zhang Q, Cobat A, Bastard P, Notarangelo LD, Su HC, Abel L, Casanova JL, COVID Human Genetic Effort*. Association of rare predicted loss-of-function variants of influenza-related type I IFN genes with critical COVID-19 pneumonia. Journal of Clinical Investigation 2021;131(15):e152474. Flores C es miembro del grupo*. doi: https://doi.org/10.1172/jci152474

Suarez-Pajes E, Diaz-de Usera A, Marcelino-Rodriguez I, Guillen-Guio B, Flores C. Genetic ancestry inference and its application for the genetic mapping of human diseases. International Journal of Molecular Sciences 2021;22(13):6962. doi: https://doi.org/10.3390/ijms22136962

Flores C. Decoding the pharmacogenetics of NSAID hypersensitivity. British Journal of Dermatology 2021;185(4):697-698. doi: https://doi.org/10.1111/bjd.20693

Ciuffreda L, Lorenzo-Salazar JM, Alcoba-Florez J, Rodriguez-Pérez H, Gil-Campesino H, Íñigo-Campos A, García-Martínez de Artola D, Valenzuela-Fernández A, Hayek-Peraza M, Rojo-Alba S, Alvarez-Argüelles ME, Díez-Gil O, González-Montelongo R, Flores C. Longitudinal study of a SARS-CoV-2 infection in an immunocompromised patient with X-linked agammaglobulinemia. Journal of Infection 2021;83(5):607-635. doi: https://doi.org/10.1016/j.jinf.2021.07.028

Hernandez-Pacheco N, Gorenjak M, Li J, Repnik K, Vijverberg SJ, Berce V, Jorgensen A, Karimi L, Schieck M, Samedy-Bates LA, Tavendale R, Villar J, Mukhopadhyay S, Pirmohamed M, Verhamme KMC, Kabesch M, Hawcutt DB, Turner S, Palmer CN, Tantisira KG, Burchard EG, Maitland-van der Zee AH, Flores C, Potočnik U, Pino-Yanes M. Identification of ROBO2 as a potential locus associated with inhaled corticosteroid response in childhood asthma. Journal of Personalized Medicine 2021;11(8):733. doi: https://doi.org/10.3390/jpm11080733

Hernandez-Beeftink T, Guillen-Guio B, Rodríguez-Pérez H, Marcelino-Rodríguez I, Lorenzo-Salazar JM, Corrales A, Prieto-González M, Rodríguez-Pérez A, Carriedo D, Blanco J, Ambrós A, González-Higueras E, Casanova NG, González-Garay M, Espinosa E, Muriel A, Domínguez D, García de Lorenzo A, Añón JM, Soro M, Belda J, Garcia JGN, Villar J, Flores C, for the Genetics of Sepsis (GEN-SEP) Network. Whole blood mitochondrial DNA copies are associated with the prognosis of acute respiratory distress syndrome after sepsis. Frontiers in Immunology 2021;12:737369. doi: https://doi.org/10.3389/fimmu.2021.737369

Mendoza-Alvarez A, Marcelino-Rodriguez I, Almeida-Quintana L, Martin-Fernandez E, Martinez-Beltran D, Almeida-Sanchez Z, Cruz-Niesvara D, Hernández-Santana G, Garcia-Robaina JC, Flores C, Callero A. First census of patients with Hereditary Angioedema in the Canary Islands. Journal of Clinical Medicine 2021;10(20):4711. doi: https://doi.org/10.3390/jcm10204711

Flores C. Marcadores genéticos en la dermatitis atópica. Journal of Investigational Allergology and Clinical Immunology 2021;31(Supp 2):1-15.
doi: NA

Villar J, Herrán-Monge R, González-Higueras E, Prieto-González M, Ambrós A, Rodríguez-Pérez A, Muriel A, Solano R, Cuenca-Rubio C, Vidal A, Flores C, González-Martín JM, García-Laorden MI. Clinical and biological markers for predicting ARDS and outcome in septic patients.
Scientific Reports 2021;11(1):22702. doi: https://doi.org/10.1038/s41598-021-02100-w

Suarez-Pajes E, Díaz-García C, Rodríguez-Pérez H, Lorenzo-Salazar JM, Marcelino-Rodríguez I, Corrales A, Zheng X, Callero A, Perez-Rodriguez E, Garcia-Robaina JC, González-Montelongo R, Flores C*, Guillen-Guio B. Targeted analysis of genomic regions enriched in African ancestry reveals novel classical HLA alleles associated with asthma in Southwestern Europeans. Scientific Reports 2021;11(1):23686. doi: https://doi.org/10.1038/s41598-021-02893-w

Área de Medioambiente

Hernández P. A., Nogami K., Padrón E., Somoza L., Amonte C., Mori T., Melián G.V., Sumino H., Kikawada Y. and Pérez N.M. (2021). Hydrochemical and Hydroacoustic Investigation of the Yugama Acid Crater Lake, KusatsuShirane, Japan. Frontiers in Earth Sciences, doi: 10.3389/feart.2021.741795.

Pankhurst M. J., Stevenson C. J. and  Coldwell B. C.(2021). Meteorites that produce K-feldspar-rich ejecta blankets correspond to mass extinctions. Journal of the Geological Society, doi.org/10.1144/jgs2021-055

Melián G. V., Toulkeridis T., Pérez N. M., Hernández P. A., Somoza L., Padrón E., Amonte C., Alonso M., Asensio-Ramos M. and Cordero M. (2021). Geochemistry of water and gas emissions from Cuicocha and Quilotoa Volcanic Lakes, Ecuador. Frontiers in Earth Sciences, doi.org/10.3389/feart.2021.741528.

Dóniz-Páez J., Becerra-Ramírez R. & Beltrán-Yanes E. (2021). Geomorfositios en el Geoparque Mundial Unesco de El Hierro (Islas Canarias, España) para fomentar el geoturismo en espacios volcánicos. Revista De Geografía Norte Grande, 80, 165-186.

Sandoval-Velasquez A., Rizzo A. L., Aiuppa A., Remigi S., Padrón E., Pérez N. M. and Frezzotti M. L. (2021). Recycled crustal carbon in the depleted mantle source of El Hierro volcano, Canary Islands. Lithos, https://doi.org/10.1016/j.lithos.2021.106414

Melián G. V., Hernández P. A., Pérez N. M., Asensio-Ramos M., Padrón E., Alonso M., Padilla G. D., Barrancos J., Sortino F., Sumino H., Rodríguez F., Amonte C., Silva S., Cardoso N., and Pereira J. M. (2021). Insights from fumarole gas geochemistry on the recent volcanic unrest of Pico do Fogo, Cape Verde. Frontiers in Earth Sciences, doi: 10.3389/feart.2021.631190

Giudicepietro F., Ricciolino P., Bianco B., Caliro S., Cubellis E., D’Auria L., De Cesare W., De Martino P., Esposito A. M., Galluzzo D., Macedonio G., Lo Bascio D., Orazi M., Pappalardo L., Peluso R., Scarpato G., Tramelli A. and Chiodini G. (2021). Campi Flegrei, Vesuvius and Ischia seismicity in the context of the Neapolitan volcanic area. Frontiers in Earth Science, doi: 10.3389/feart.2021.662113

Soubestre J., Chouet B. and Dawson P. (2021). Sources of Volcanic Tremor Associated With the Summit Caldera Collapse During the 2018 East Rift Eruption of Kılauea Volcano, Hawaii. Journal of Geophysical Research – Solid Earth, https://doi.org/10.1029/2020JB021572

García‐Hernández R., D’Auria L., Barrancos J., Padilla G. D. and Pérez N. M. (2021). Multiscale Temporal and Spatial Estimation of the b‐Value. Seismological Research Letters; doi: https://doi.org/10.1785/0220200388

Alonso M., Pérez N. M., Padrón E., Hernández P. A., Melián G. V., Sumino H., Padilla G. D., Barrancos J., Rodríguez F., Dionis S., Asensio-Ramos M., Amonte C., Silva S. and Pereira J. M. (2021). Changes in the thermal energy and the diffuse 3He and 4He degassing prior to the 2014-2015 eruption of Pico do Fogo volcano, Cape Verde. Journal of Volcanology and Geothermal Research, https://doi.org/10.1016/j.jvolgeores.2021.107271

Hernández P. A., Melián G. V., Asensio-Ramos M., .Padrón E., Sumino H., Pérez N. M., Padilla G. D., Barrancos J., Rodríguez F., Amonte C., Arcilla C. and Mahar Lagmay A. (2021). Geochemical and isotopic evidence of volcanic plumbing system processes from fumarolic gases of Taal volcano, Philippines, prior to the January 2020 eruption. Chemical Geology, https://doi.org/10.1016/j.chemgeo.2021.120216

Somoza L., Medialdea T., González F.J., Machancoses S., Candón J.A., Cid C., Calado A., Afonso A., Pinto Ribeiro L., Blasco I., Alburquerque M., Asensio-Ramos M., Bettencourt R., Carreira-Silva M., De Ignacio C., López-Pamo E., Ramos B., Rincón-Tomás B., Santofimia E., Souto M., Tojeira I., Viegas C. and Madureira P. (2021). High-Resolution Multibeam Bathymetric Map of the northern Mid-Atlantic Ridge at 45-46º N: The Moytirra hydrothermal field. Journal of Maps, 17:2, 184-196, DOI: 10.1080/17445647.2021.1898485

Amonte, C., Asensio-Ramos, M., Melián, G.V., Pérez N. M., Padrón E., Hernández P. A., Rodríguez F., D’Auria L. &  López D. (2021).  Hydrogeochemical temporal variations related to changes of seismic activity at Tenerife, Canary Islands. Bull Volcanol 83, 24,  https://doi.org/10.1007/s00445-021-01445-4

Padrón E., Pérez N. M., Hernández P. A., Melián G., Asensio-Ramos M., D’Auria L., Rodríguez F, Alonso M., Amonte C., Padilla G. D., Barrancos J.,  Calvo D.,   Coldwell B. and Pankhurst M. J. (2021). Changes in diffuse degassing from the summit crater of Teide volcano (Tenerife, Canary Islands) prior to the 2016 Tenerife long-period seismic swarm. Journal of Geophysical Research: Solid Earth, 126, e2020JB020318. https://doi.org/10.1029/2020JB020318

Sánchez-Cañadillas E., Carballo J., Padrón E., Hernández-Marrero J. C., Melián G. V., Navarro-Mederos J. F., Pérez N. M. and Arnay-de-la-Rosa M. (2021). Dietary changes across time: studying the indígenous period of La Gomera using δ13C and δ15N stable isotope analysis and radiocarbon dating. American Journal of Physical Anthropology, DOI: 10.1002/ajpa.24220

Rodríguez F., Pérez N. M., Melián G. V., Padrón E., Hernández P. A., Asensio-Ramos M., Padilla G. D., Barrancos J. and D’Auria L. (2021). Exploration of deep-seated geothermal reservoirs in the Canary Islands by means of soil CO2 degassing surveys. Renewable Energy, https://doi.org/10.1016/j.renene.2020.09.065

Ledo J., García-Merino M., Larnier H., Ślęzak K., Piña-Varas P., Marcuello A., Queralt P., Pérez N. M., Schmincke H.-U. and Sumita M. (2021). 3D electrical resistivity of Gran Canaria island using magnetotelluric data. Geothermics, https://doi.org/10.1016/j.geothermics.2020.101945

Couperthwaite F. K., Morgan D. J., Pankhurst M. J., Lee P. D. and Day J. M. D. (2021). Reducing epistemic and model uncertainty in ionic interdiffusion chronology: A 3D observation and dynamic modelling approach using olivine from Piton de la Fournaise, La Réunion. American Mineralogist, https://doi.org/10.2138/am-2021-7296CCBY